https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Critical role for iron accumulation in the pathogenesis of fibrotic lung disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41157 Wed 15 Feb 2023 10:57:18 AEDT ]]> Detailed DNA methylation characterisation of phyllodes tumours identifies a signature of malignancy and distinguishes phyllodes from metaplastic breast carcinoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54801 Wed 13 Mar 2024 11:41:50 AEDT ]]> Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39910 Thu 30 Jun 2022 12:44:37 AEST ]]> Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33793 –/–) mice had reduced mucin (MUC) 5 AC levels, but not MUC5B levels, in the airways as compared with wild‐type (WT) mice. Fbln1c interacted with fibronectin and periostin that was linked to collagen deposition around the small airways. Fbln1c–/– mice with AAD also had reduced numbers of α‐smooth muscle actin‐positive cells around the airways and reduced airway contractility as compared with WT mice. After HDM challenge, these mice also had fewer airway inflammatory cells, reduced interleukin (IL)‐5, IL‐13, IL‐33, tumour necrosis factor (TNF) and CXCL1 levels in the lungs, and reduced IL‐5, IL‐33 and TNF levels in lung‐draining lymph nodes. Therapeutic targeting of Fbln1c reduced the numbers of GATA3‐positive Th2 cells in the lymph nodes and lungs after chronic HDM challenge. Treatment also reduced the secretion of IL‐5 and IL‐13 from co‐cultured dendritic cells and T cells restimulated with HDM extract. Human epithelial cells cultured with Fbln1c peptide produced more CXCL1 mRNA than medium‐treated controls. Our data show that Fbln1c may be a therapeutic target in chronic asthma.]]> Thu 28 Oct 2021 13:02:39 AEDT ]]> Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5292 Sat 24 Mar 2018 07:46:29 AEDT ]]> Lung development and emerging roles for type 2 immunity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47749 Fri 27 Jan 2023 09:57:00 AEDT ]]>